Circadian  Rhythm  Research detailed analysis

Circadian Rhythms are our biological clocks;   these tells us when we should sleep and also when we should wake up, but not limited to the previous.  Researchers also believe that the rhythms control body temperature, mental awareness, pain awareness,  and also hormone production.(1)  Two studies will be examined and reviewed in the following paper, to help better understand the new findings about  Circadian  Rhythm  The first article,  “Circadian  Rhythms”, reviews the work of investigators from  Northwestern  University.  The investigators produced results that will  help better understand the role our biological clocks play in  our daily routines.  The article also informs us  that;  the  Circadian  Rhythms  of animals and plants are controlled by external and internal variables.(1)          Investigators, using forward genetics,  cloned  the  Clock gene into mice.  They cloned the  gene to isolate it,  and  for the added ability  to  later screen the behavior of the mice.  The screening is done to gain better knowledge of  the Clock gene they are implementing in the mice.  By  manipulating  the  Circadian  Rhythm  of  the  mice,  the  investigators  believe  they  will  be  able  to  later  manipulate  the  Circadian  Rhythm  of  Humans.(1)

The investigators believe that  the research performed will  later lead to a better understanding of  the Clock gene,  making it possible to  change  the  Sleep/Wake  Cycle  of  Humans.  They  also  believe  it  will  then  be   possible  to  make  new  and   more  effective  applications  for  use  in   delivering   drugs  to  patients.(1)

The research could  have endless uses though; considering there is  so much unknown about all the components of the  Circadian  Rhythm.    One more possible use could be the  use  of this research to advance medicine development,  leading  to  an end of all sleeping disorders.

The second article;  “Researchers  Uncover  Sleep/Wake  Gene” reviews the research performed by  Michael  Young, and colleagues from  Rockefeller  University.   The research led  to  a finding of a gene double-time, also  known  as  DBT.  The researchers believe that  DBT  controls the molecular cycles of the Circadian rhythm.  They found this by studying the proteins of the  DBT, and came to  a theory that it monitors productions of proteins that directly effect our  Circadian  Rhythm. (2)

The researches found that;  DBT  is  what controls the amount  of   PER  and  TIM proteins dispersed and stored throughout a day cycle.(2)  The  study  explains  that  PER  and  TIM   proteins are known to be associated directly with the balancing of the daily  “rhythm”.   For example; When the human body knows it is time to  rest.  The  DBT  gene  is  found  to  be  a  critical  part  of the  rhythm,  and  if  it  were  to  be    eliminated  it  would  end  in  death.(2)


Researchers of this study are also making an attempt to better understand the  Circadian  Rhythm.  They believe this  work will later help  lead to many new discoveries about the  Circadian  Rhythm.  Possibilities they foresee;  include the following:  helping  the night workforce to act as  if  it were daytime, helping to improve the delivery of medicines to patients,  and  also helping to end sleeping disorders. (2)    Another possible application for  this  study could include the  ability to induce sleep,  instead of having to use sedatives that are sometimes fatal and damaging by  their  nature.


The  study doesn’t lack any  variables  yet to be considered.  However the study could be continued by cloning the  DBT gene into a  test  subject, allowing for a better understanding of the gene.  There  are many unknowns with the many parts  of the  Circadian  Rhythm;  therefore,   one could never really know the total value of this study until the rhythm is fully understood in whole.

The two articles give  us  a better understanding of where this scientific research is heading in the future.  Scientists are discovering new genes and other variables that directly relate human biological clocks.  Most likely that  will continue to happen  until the rhythm is fully understood,  and been experimented on in every possible application.  The scientistsin these articles believe they  have tested every variable,  but  until trial and error  is  fully complete  this continues to be unknown  to  all.  However; the discoveries they have made are proven to  be extremely valuable to  research  at  this  current  time.

The two articles also help to relate differing factors  of the  Circadian Rhythm.  Most  of the many parts  of  the  Circadian Rhythm are directly  related, leading to a very complicated system.  The sunlight outside to the a  single Clock gene controls the daily  rhythms.   Other variables would include environmental temperature and  the  DBT  gene.   The professors and  authors  of the studies have shown that a better understanding is eminent in the  future.  Throughout there studies;  it  is  found that there is a new direction in all forms.   Possibly  even  linking  our  Circadian Rhythm  to  the  amount  of   memory  one  can   have  in  a lifetime;  or  even  linking  it  to  feelings  we  have  about  someone



  1. Russo, Eugene “Circadian Rhythms” The Scientist 13[21]:16, Oct. 25, 1999
  2. Russo, Eugene “Researchers Uncover Sleep/Wake Gene”  The Scientist  12 [16]: 13, Aug. 17, 1998

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