Cholecystokinin plays a fundamental role in facilitating digestion within the small intestine. Mucosal epithelial cells in the duodenum secrete the hormone and stimulate the delivery of pancreatic digestive enzymes and bile from the gallbladder into the small intestine. Neurons in the Centricnervous system also produce Cholecystokinin, which is highly present in the brain. However, Cholecystokinin facilitates digestion from different facets. The presence of partially digested proteins and fats stimulate its secretion. In contrast, it stimulates the secretion of digestive juices from the pancreas and the delivery of bile into the small intestine.
Structure and distribution of CCK
CKK effect on energy balance
Different laboratory experiments have proven the CKK peptide to influence energy balance in mammals with age. Peptide hormones influenced different energy determinant effects such as food intake, body temperatures, and body weight through either an anabolic or catabolic effect on the specimen (1180). However, peptides do not perform a standard role in the regulation of energy over a lifetime, but their roles and interaction effects on energy balance vary. At a young age, energy levels exceed calorie intake in young adults, both anabolic and catabolic mechanism balance. However, aged mammals exhibit excess catabolic mechanisms(1180). The gastrointestinal peptide plays various roles in forwarding and digesting food besides causing the effect of feeling full. Its presence in the brain-gutt axis can influence cerebral functions related to energy balance. According to …., food intake stimulates the production of CCK in the upper gastrointestinal tract ad in the hypothalamus(1182). The nucleus of the solitary tract asses and integrity visceral afferent signals such as the CKK related signals while the dorsal motor nuclei provide outbound signals towards neurons of the rostral medullary raphe influence afferent responses. The system work depends on negative meal negative feedback satiety signal, thus determining the short term food intake control.
Effects on the endocrine system
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